13 July 2016
Conference
Session 1: Inaugural keynote

Welcome
4:00 pm Registration
5:30-6:00 pm Welcome message from the Council of Leon by Councillor for Culture, Heritage and Tourism (Miss Margarita Torres Sevilla)
6:00-7:00pm Keynote speaker: Dr. Gerald Spaeth, Département de Parasitologie et Mycologie Institut Pasteur, Paris, France "TARGETING HOST/PARASITE INTERACTION FOR ANTI-LEISHMANIAL DRUG DISCOVERY". Chairperson, Dr. Babu L. Tekwani
7:00-8:00pm Keynote speaker: Dr. Jorge Alvar, DNDi Geneva, Switzerland "ADVANCES IN VISCERAL LEISHMANIASIS TREATMENT: SUCCESSES, PITFALLS AND HOPES". Chairperson, Dr. Francisco A. Rojo Vázquez
8:00-9:00pm Guided tour to Old City of León.
9:00-10:00pm Opening Reception.

14 July 2016
Conference

Registration
Breakfast


Session 2: Biology and Pathogenesis
Chairperson: Dr. Manuel Fresno

8:30-9:10am PS-1: Dr. Dan Zilberstein, Technion Israel Institute of Science, Haifa, Israel "SIGNALING PATHWAYS IDENTIFIED BY SYSTEMS ANALYSIS OF LEISHMANIA DIFFERENTIATION".
9:10-9:35am IS-1: Dr. Birgitta Knudsen, Department of Molecular Biology and Genetics, Aarhus University, Denmark. "NEW TOOLS FOR DIAGNOSIS OF INFECTIOUS DISEASES".
9:35-9:50am IS-2: Luis Rivas López, Centro de Investigaciones Biológicas (CSIC) Madrid, Spain "IS THE LIPID MATRIX OF LEISHMANIA A DESPISED TARGET FOR CHEMOTHERAPY? A PEPTIDE-BASED APPROACH".
9:50-10:05am CS-1: Dr. Albert Descoteaux, INRS Institute Armand-Frappier, Laval Canada "TRAFFICKING OF LEISHMANIA VIRULENCE FACTORS WITHIN INFECTED MACROPHAGES".
10:05-10:20am CS-2: Dr. Christelle Cren-Travaillé, Institute Pasteur Paris (France) "HOW AFRICAN TRYPANOSOMES REMAIN TRANSMISSIBLE IN THE MAMMALIAN HOST?".
10:20-10:30am Dr. Una Ryan, School of Veterinary and Life Sciences, Murdoch University, Western Australia, Australia "APPLICATION OF PLATFORM TECHNOLOGIES TO THE DETECTION AND CHARACTERISATION OF CRYPTOSPORIDIUM".
10:30-10:40am Dr. María Pereira, Global Health and Tropical Medicine, Universidade Nova de Lisboa, Lisboa, Portugal "LEISHMANIA INFANTUM INFECTION: THE DOUBLE FACE OF DOG´S NEUTROPHILS".

10:40-11:20am Break.

11:20-12:20am Guided tour of San Isidoro.


Session 3: Global challenges & opportunities
Chairperson: Dr. Rosa M. Reguera

12:20-12:45pm IS-3: Dr. Pierre Dorny, Institute of Tropical Medicine, Antwert, Belgium "TAENIA SOLIUM CYSTICERCOSIS: CHALLENGES OF APPLYING NOVEL CONTROL TOOLS".
12:45-1:10pm IS-4: Dr. Critina Donini, Medicines for Malaria Venture, Geneva (Switzerland) "HOW CAN WE ACCELERATE DRUG DEVELOPMENT THROUGH INNOVATIVE PHASE I AND PROOF OF CONCEPT STUDIES?".
1:10-1:25pm CS-3: Dr. Guadalupe Miró, Dpt. Sanidad Animal, Universidad Complutense de Madrid, Madrid, Spain "CANINE AND FELINE LEISHMANIOSIS: CURRENT STATUS IN EUROPE".
1:25-1:40pm CS-4: Dr. Marisol Arias, Faculty of Veterinary Medicine, University of Santiago de Compostela, Lugo, Spain "ELIMINATING THE RISK OF FOODBORNE TREMATODOSES BY MEANS OF THE OVICIDE FUNGUS MUCOR CIRCINELLOIDES".
1:40-1:50pm Dr. Estefania Calvo-Álvarez, Institute Pasteur, Paris, France "FROM THE FLY TO THE HOST: SENSING IN AFRICAN TRYPANOSOMES".

1:50-3:30pm Lunch and Break


Session 4: New Drug Discovery
Chairperson: Dr. Babu L. Tekwani

3:30-4:10pm PS-3: Dr. Vincent O'Connor, Professor of Neuroscience. Centre for Biological Sciences. University of Southampton "THE NOVEL CYCLO-OCTADEPSIPEPTIDE ANTHELMINTIC EMODEPSIDE; MODE OF ACTION AND SPECTRUM OF ACTIVITY".
4:10-4:35pm IS-5: Manu de Rycker, Drug Discovery Unit, University of Dundee | Dundee DD1 5EH | UK "DISCOVERY AND LEAD-OPTIMISATION OF A PROMISING NEW ANTILEISHMANIAL COMPOUND SERIES WITHIN AN ACADEMIC-INDUSTRY PARTNERSHIP".
4:35-5:00pm IS-6: Dr. Arturo San Feliciano, Dpt. Pharmaceutical Chemistry, University of Salamanca, Spain "DISCOVERY OF NEW MOLECULES AGAINST NTDs THE USAL EXPERIENCE".
5:00-5:25pm IS-7: Dr. Rosa M. Reguera, Dpt. Biomedical Sciences, University of León, León, Spain "A DRUG DISCOVERY “EX VIVO” PLATFORM AGAINST VISCERAL LEISHMANIASIS".


Session 4 (Parallel 1): New Drug Discovery
Chairperson: Dr. Rafael Balaña Fouce

6:00-6:15pm CS-5: Dr. Juan Cantizani, Molecular Discovery ResearchGSK Tres Cantos, Madrid (Spain) "GSK MOLECULES AND MODELS TO FIND NEW ANTI-LEISHMANIAL DRUGS".
6:15-6:30pm CS-6: Dr. Nestor Carballeira, Department of Chemistry, University of Puerto Rico, San Juan, Puerto Rico, USA. "NATURAL MARINE AND TERRESTRIAL LIPIDS AS NEW AGENTS AGAINST LEISHMANIASIS".

6:30-6:40pm Dr. Concepción Alonso, Dpt. de Química Orgánica I, Universidad del País Vasco, Vitoria-Gasteiz, Spain "DESIGN AND SYNTHESIS OF TOPOISOMERASE I INHIBITORS WITH ANTILEISHMANIAL ACTIVITY".
6:40-6:50pm Dr. Jan Carlo Delorenzi, Hebron Pharmaceutical Group, Mackenzie Presbyterian University, Sao Paulo, Brazil "18-METHOXYCORONARIDINE (18-MC): INNOVATIVE ORAL DRUG FOR LEISHMANIASIS TREATMENT"


Session 4 (Parallel 2): New Drug Discovery
Chairperson: Dr. María Martínez Valladares

6:00-6:10pm Dr. Marisol Arias, Faculty of Veterinary Medicine, University of Santiago de Compostela, Lugo, Spain "AN APPROACH TO PREVENT CUTANEOUS LARVA MIGRANS BY A SUSTAINABLE STRATEGY".
6:10-6:20pm Aikaterini Lalatsa, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK "ORAL NANOMEDICINES FOR THE TREATMENT OF PARASITIC DISEASES".
6:20-6:30pm Dr. Dolores R. Serrano Dpt Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain "ENGINEERING SYNERGISTICALLY ACTIVE AND BIOAVAILABLE COST-EFFECTIVE MEDICINES FOR NEGLECTED TROPICAL DISEASES; THE ROLE OF EXCIPIENTS".
6:30-6:40pm Dr. Rosario Díaz, Instituto de Parasitología y Biomedicina "López-Neyra" CSIC, Granada, Spain "DRUGGING PARASITE KINOME: FROM COMPOUND REPURPOSING TO HIT-TO-LEAD DISCOVERY FOR SLEEPING SICKNESS".
6:40-6:50pm Dr. Rocio Paucar, Dpt. Organic Chemistry. Institute of Tropical Health, University of Navarra Pamplona, Spain "IN VITRO AND IN VIVO ANTI-TRYPANOSOMA CRUZI ACTIVITY OF NEW ARYLAMINE MANNICH BASE DERIVATIVES".

7:00-8:00pm San Isidoro's Museum guided tour.

8:00-9:00pm Dinner

15 July 2016
Conference
Keynote Conference

8:30-9:30am Keynote speaker: Dr. Carlos Lanusse, Centro de Investigación Veterinaria de Tandil (CIVETAN) Argentina "CHALLENGES TO OPTIMIZE THE ACTIVITY AND EXTEND THE LIFESPAN OF ANTHELMINTIC MOLECULES IN THE PRESENCE OF RESISTANT HELMINTH POPULATIONS". Chairperson: Dr. Francisco A. Rojo Vázquez


Session 5: Multiomics
Chairperson: Dr. Rosario Díaz González

9:30-10:10am PS-4: Dr. Marc Ouellette, Centre de Recherche en Infectiologie du Centre De Recherche, Université Laval, Québec, Canada "GENOMICS OF DRUG RESISTANCE IN LEISHMANIA".
10:10-10:35am IS-8: Dr Cinzia Cantacessi, Department of Veterinary Medicine.University of Cambridge, Cambridge CB3 0ES, UK "SUPPRESSION OF INFLAMMATION BY HELMINTHS – A ROLE FOR THE GUT MICROBIOTA?".
10:35-10:50am CS-7: Dr. Martin Olivier, Research Institute of McGill University Health center, Montreal (Canada) "LEISHMANIAL SANDFLY VECTOR NANOBIOME: IMPACT ON CUTANEOUS LEISHMANIASIS".
10:50-11:05am CS-8: Dr. Eva Rico, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK "GENOME-WIDE SELECTIVE SCREEN IDENTIFIES A NEGATIVE REGULATOR OF TRANSMISSION STAGE-ENRICHED MEMBERS OF THE TRYPANOSOMA BRUCEI CELL SURFACE PHYLOME".
11:05-11:40am Break


Session 6: Molecular Targets
Chairperson: Dr. Estefanía Calvo Álvarez

11:40am-12:10pm PS-5: Dr. Luis Ignacio Álvarez, Centro de Investigación Veterinaria de Tandil (CIVETAN), Argentina "PHARMACOKINETIC-PHARMACODYNAMIC RELATIONSHIPS OF ANTHELMINTIC DRUGS".
12:10-12:35pm IS-9: Dr. Una Ryan, School of Veterinary and Life Sciences, Murdoch University, Western Australia, Australia "TARGET VALIDATION OF THE INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH) GENE IN CRYPTOSPORIDIUM USING PHYLOMER PEPTIDES".
12:35-12:50pm CS-9: Dr. Bárbara Papadopoulou, Centre de Recherche en Infectiologie, Université Laval, Québec, Canada "RNA-BINDING PROTEINS CONTROLLING LEISHMANIA INTRACELLULAR DEVELOPMENT".
12:50-13:05pm CS-10: Dr. Melissa L. Sykes, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Australia "SELECTION OF COMPOUNDS FOR TARGET STUDIES IN THE UTILIZING IMAGINE AND REDOX BASED".
13:05-13:20pm Dr. Monika Gulia-Nuss, University of Nevada, Reno, USA "ROLE OF MOSQUITO INSULIN SIGNALING IN PARASITE DEVELOPMENT".

13:40-15:30pm Lunch and Break


Session 7: Drug Resistance and Translational Research
Chairperson: Dr. María Martínez Valladares

3:30-4:10pm PS-6: Dr. Manuel Fresno, Centro de Biología Molecular Severo Ocho (CSIC) Madrid, Spain "UNDERSTANDING THE COMPLEX IMMUNOPATHOGENESIS OF TRYPANOSOMA CRUZI INFECTION".
4:10-4:35pm IS-10: Dr. Francisco Rojo , Dpt. Animal Health, University of León, León Spain "INTEGRATED CONTROL OF SOME HELMINTH INFECTIONS OF ANIMALS AND MEN".
4:35-5:00pm IS-11: Dr. Jürgen Krücken, Institute for Parasitology and Tropical Veterinary Medicine Freie Universität, Berlin, Germany "ANTHELMINTIC RESISTANCE RESEARCH IN VETERINARY PARASITOLOGY AS A BLUE PRINT TO TACKLE AN EMERGING ISSUE IN HUMANS?".
5:00-5:15pm CS-11: Dr. Harry De-Koning, University of Glasgow, Glasgow, UK "HIGHLY CONSERVED TRANSPORTER FAMILIES INVOLVED IN HIGHLY SPECIFIC DRUG TRANSPORT IN KINETOPLASTID PARASITES".
5:15-5:30pm CS-12: Dr. Richar Rodríguez-Hidalgo, Centro Internacional de Zoonosis, Universidad Central del Ecuador, Quito, Ecuador "FIRST REPORT OF ACARICIDE RESISTANCE (AMITRAZ, ALPHA-CYPERMETHRIN AND IVERMECTIN) ON RHIPICEPHALUS MICROPLUS IN ECUADOR".
5:30-5:40pm Dr. Laura González, Biología y control de enfermedades Infecciosas, Universidad de Antioquia, Antioquía, Colombia "ALCOHOL DEHYDROGENASE AND ALDO-KETO REDUCTASE ARE INVOLVED IN THE MECHANISM OF RESISTANCE TO BENZNIDAZOL TRYPANOSOMA CRUZI".


Session 8: Concluding keynote
Chairperson: Dr. Rafael Balaña Fouce

6:30-7:30pm Concluding conference: Dr. Babu L. Tekwani, National Center for Natural Products Research, Mississippi USA "NEW ANTIPARASITIC DRUG DISCOVERY FROM NATURAL PRODUCTS: CHALLENGES AND OPPORTUNITIES".

9:00-11:00pm Closing Banquet and Awards